In 2003, the international myeloma working group imwg announced a consensus on diagnostic criteria for classifying and differentiating plasma cell pc proliferative disorders including symm. Dec 01, 2014 recently, on october 27, 2014, the international myeloma working group imwg. International myeloma working group updated criteria for. The present disease definitions of smouldering multiple myeloma and multiple myeloma were reported by the international myeloma working group imwg in 2003. Aug 16, 2018 the revised international myeloma working group criteria for the diagnosis of multiple myeloma and related disorders are shown on table 1. These changes are based on the identification of biomarkers associated with near inevitable development of crab features in patients. International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders. The updated criteria for the diagnosis of myeloma represent a paradigm shift in the approach to myeloma and have considerable impact on the management of the disease. International myeloma working group recommendations for the. Mar 15, 2017 in november 2014, the international myeloma working group imwg revised the diagnostic criteria for several reasons. Revised international myeloma working group imwg criteria. For decades the diagnosis of multiple myeloma required the presence of endorgan damage. International myeloma working group imwg offshoot of international myeloma foundation.
In 2014, the international myeloma working group imwg panel consensus 1 updated 2003 criteria for the diagnosis of multiple myeloma by adding three new biomarkers, along with a few other modifications. Theses recommendations are excerpted from palumbo a et. The diagnostic and response criteria recommended are primarily derived from the international myeloma working group, with certain updates and clarifications. The international myeloma working group imwg recently updated the diagnostic criteria for myeloma to include biomarkers, in addition to the existing crab features. New diagnostic criteria for multiple myeloma clinical. International myeloma working group consensus approach to the. Furthermore, detection of minimal residual disease is important for prognosis determination and treatment planning, and it has.
Updated international myeloma working group criteria. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders. Kastritis et al greek group 2014 identified 965 14% of patients with smouldering myeloma to have 1 focal lesion on spinal mri and the median time to progression for this group was 15 months, with 69% of patients progressing by 2 years and 85% by 3 years. Biopsyproven solitary lesion of bone or soft tissue with evidence.
The diagnosis of multiple myeloma requires the presence of one or more myeloma defining events mde in addition to evidence of either. The revised international myeloma working group criteria for the diagnosis of multiple myeloma and related disorders are shown on table i 1. Updated diagnostic criteria and staging system for multiple. The first consensus guideline was published in 2003 and the first annual brainstorming summit was organized in barcelona in 2010. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any di. The detection of bone and bone marrow lesions is crucial in the investigation of multiple myeloma and often dictates the decision to start treatment. Apr 25, 2018 in 2014, the international myeloma working group imwg panel consensus 1 updated 2003 criteria for the diagnosis of multiple myeloma by adding three new biomarkers, along with a few other modifications. New diagnostic criteria for myeloma nssg haematology. According to the revised international myeloma working group, diagnostic criteria for multiple myeloma include one of these major signs, confirmed by a bone marrow biopsy. Serum monoclonal protein nonigm type, 3 gdl clonal bone marrow plasma cells, 10%. The international myeloma working group imwg and mayo clinic have established almost identical criteria for the diagnosis of the plasma cell proliferative disorders.
Imwg criteria for the diagnosis of myeloma and guidelines for the diagnostic workup of myeloma criteria for a diagnosis of myeloma followed by the examinations, tests, and imaging studies that are recommended by the working group for the diagnosis of myeloma and related organ dysfunction. Guidelines for serum free light chain analysis in multiple myeloma and related disorders 2009 25. Develop guidelines for diagnosis, management, response criteria, etc. International myeloma working group diagnostic criteria for multiple myeloma and related plasma cell disorders disorder disease definition nonigm monoclonal gammopathy of undetermined significance mgus all 3 criteria must be met. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any diff erences in outcome that might occur as a result of the new disease defi nition. Mar 14, 2016 purpose the aim of the international myeloma working group was to develop practical recommendations for the diagnosis and management of multiple myelomarelated renal impairment ri. The international myeloma working group imwg emerged from the imfs scientific advisory board which was established in 1995.
Imwg updated criteria for the diagnosis of myeloma this paper, produced by an expert panel of the international myeloma working group imwg, provides consensus updates on the disease definition of myeloma which now include validated biomarkers in addition to the presence of the traditional crab criteria. Prior to the 2014 imwg diagnostic criteria, the clinical paradigm for plasma cell dyscrasia without endorgan damage used to be watch and. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. International myeloma working group imwg criteria for the diagnosis of multiple myeloma. The revised imwg diagnostic criteria for smm and mm are listed in table 2. International consortium of 200 leading myeloma researchers. Consensus guidelines on the diagnosis of multiple myeloma and. For a diagnosis of sp, the international myeloma working group imwg requires all four of the following criteria be metref1. Plasmacytoma bone lesion extramedullary soft tissue plasmacytoma. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment which is relatively insensitive. International myeloma working group diagnostic criteria for multiple myeloma and related plasma cell disorders disorder disease definition nonigm mgus all three criteria must be met.
These new criteria add myeloma defining events, the presence of any one of. Although the international myeloma working group has taken a pragmatic approach in recommending a range of possible imaging investigations including lowdose ct, fdg petct, and mri for patients with a new potential diagnosis of myeloma, the high sensitivity of wholebody mri is explicitly acknowledged 6,35 and it is now recommended as. The international staging system is the current standard for staging of myeloma. Jul 20, 2006 the international myeloma working group has developed new standard diagnostic criteria 8 and a new international staging system iss for multiple myeloma, 9 which are being widely accepted as the. Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. What are the imwg diagnostic criteria for multiple myeloma.
International myeloma working group updated criteria for the diagnosis of multiple myeloma. Serum monoclonal protein nonigm type 200 leading myeloma researchers. New systems have emerged for diagnosis, staging and response assessment in multiple myeloma mm. The international myeloma working group imwg has updated the diagnostic criteria for mm in 2014, adding 3 specific biomarkers that. The diagnostic criteria for multiple myeloma and related disorders have been updated by the international myeloma working group.
New imwg diagnostic criteria allows earlier diagnosis ash. International uniform response criteria for multiple myeloma. Multiple myeloma mm has been traditionally defined by the presence of endorgan damage, specifically, hypercalcemia, renal failure, anemia, and bone lesions crab features that are felt to be a consequence of the underlying clonal plasma cell proliferation. Imwg criteria for the diagnosis of mm inl myeloma fn. Risk stratification of smoldering multiple myeloma. International myeloma working group updated criteria for the. This international myeloma working group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable crab features hypercalcaemia, renal failure, anaemia, and bone lesions. Table 3 diagnostic criteria diagnosis diagnostic criteria. Imwg criteria for the diagnosis of myeloma and guidelines for. Multiple myeloma the path to diagnosis mymyelomateam. International myeloma working group research collaboration. Overall, only 35% of the patients are younger than 65 years at the time of diagnosis, whereas the remaining twothirds are older. It became clear that there was a need to conduct collaborative research and produce consensus guidelines for the myeloma community.
Imwg updated criteria for the diagnosis of myeloma academy. International myeloma working group consensus criteria for. Introduction multiple myeloma is a cytogenetically heterogeneous. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any differences in outcome that might occur as a result of the new disease definition. Recent advances in the treatment of multiple myeloma have increased the need for accurate diagnosis of the disease. Rajkumar sv, dimopoulos ma, palumbo a, blade j, merlini g, et al. International myeloma working group imwg criteria for the. International myeloma working group guidelines for the. Consensus statement on diagnostic requirements, response criteria and treatment recommendations by the international myeloma working group november 2012. Kyle r, child ja, anderson k, barlogie b, bataille r, bensinger w, et al. In 2014, the international myeloma working group revised the diagnostic criteria for multiple myeloma. What are the imwg diagnostic criteria for solitary. Criteria for diagnosis, staging, risk stratification and.
45 1396 1276 1342 866 595 558 76 1343 612 1035 215 477 636 159 1648 1407 614 595 284 306 194 1197 174 876 1506 1498 163 806 1310 245 796 527 1400 183 246 686 1086 7 704